Welcome Seminar - Personalized Theragnostic Approaches: from 3D Tissue Models to Medical Devices - Laura Russo

Martedì 25 Giugno 2024, ore 13
Edificio Asclepio U8-Aula 4

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The development of human tissue models is crucial for advancing healthcare management by generating in vitro organs for drug screening and personalized tissue engineering solutions. To achieve this goal, biomaterial mimicking the Extracellular Matrix (ECM) morphology and signaling capacity must be generated. The ECM plays a key role in modulating cell fate, mediated by specific interactions with cell receptors. The generation of multifunctional materials, employable in designing functional organ-like constructs, still represents an open challenge in the field. In this context, the glycosignature of the ECM plays a pivotal role in modulating cell fate through specific interactions with cell receptors. This complex interplay is needed to generate tissue in vitro models that accurately patient-specific physiological or pathological conditions. Leveraging technological adv ancements, such as Artificial Intelligence (AI) algorithms and automated manufacturing systems, including 3D printing and 3D Bioprinting, has become instrumental in overcoming obstacles associated with traditional combinatorial and artisanal chemical approaches used to develop diagnostic and therapeutic solutions. In this presentation, I will discuss recent efforts to generate 3D in vitro tissues and multifunctional medical devices with patient-required features, utilizing also AI algorithms.

Laura Russo is Associate Professor at University of Milano-Bicocca, Adjunct Lecturer at National University of Galway – CURAM (Center of Excellence for Medical Devices). From October 2023 she is also Visiting Researcher at the Imperial College of London.
• PhD in 2012, University of Milano-Bicocca, working on a multidisciplinary project exploiting glycoscience in the field of tissue engineering.
• 2016 Principal Investigator at Cùram, National University of Ireland - Galway where awarded the SFI Starting Investigator Research Grant (SIRG)
• 2017 Researcher at the University of Milano – Bicocca and Adjunct Lecturer at the National University of Ireland - Galway.
• 2017 awarded the prestigious Junior Research Award for Organic Chemistry in Life Science of the Italian Chemical Society for her scientific contribution on organic chemistry applied to the biomedical and life science field.
• 2019 Advisory Board Member of Biocompatibiliyty Innovation – start up in the field of medical device. 
• 2022 Founder of Resyde srl – start up in the field of medical devices.
LR is author of 68 article on peer reviewed publications, 14 Book chapters, 28 Invited Lectures at scientific national and international conferences. Her research is focused on synthesis and generation of biomaterials for the development of: multifunctional medical devices, including 3D in vitro tissue models, regenerative medicine, patient-personalized biosensors and AI/ML predictive synthesis platforms.