Monza, 29th March 2021, 5 pm
Webinar Online
Meeting link: https://unimib.webex.com/
Meeting number:121 898 4580
Password: Seminario (73646274 from phones)
Neurotoxicity induced by chemotherapy: studies of molecular mechanisms in preclinical models
Chemotherapy has significantly increased life expectancy for oncological patients. However, neurological complications such as chemotherapy-induced peripheral neuropathy (CIPN) can have a debilitating effect on the quality of patients’ lives, which could even lead them to interrupting antineoplastic therapies. Unfortunately, today there are no known effective treatments to either prevent or treat toxic side effects from chemotherapy on the peripheral nervous system.
Therefore, it’s essential to investigate the mechanisms which lead to CIPN to be able to interrupt the resulting degenerative process in time. In particular, the aim of this meeting will be to discuss some molecular targets responsible for peripheral neurotoxicity resulting from antineoplastic proteasome inhibitor bortezomib, such as post-translational modifications of tubulin and alteration of the axonal transport of mitochondria.
Cristina Meregalli, PhD, Assistant Professor of Human Anatomy, School of Medicine and Surgery, University of Milano-Bicocca
The seminar will be registered.