Wednesday 25 January 2023,
13:00 Building Asclepio U8 - Room 1
Blended mode
webex link: https://unimib.webex.com/webappng/sites/unimib/meeting/info/5243ecc6dbb14402a6837b7b44d6f847?siteurl=unimib&MTID=mdab6c9f3a228835c2f2cc7836c613bb0
Spatial omics using matrix-assisted laser desorption/ionisation mass spectrometry imaging (MALDI-MSI) is a unique tool that enables the detection of thousands of biomolecules entirely in situ, maintaining their spatial relationship within the cellular network of tissue. Thus, this technology offers a complementary molecular dimension that can be integrated with digital pathology to shed further light on disease state and progression. In this seminar, we will cover some of the fundamental principles of MALDI-MSI and describe some of the recent advancements and applications of this technology within the field of molecular pathology.
Dr. Andrew Smith is currently an Assistant Professor at the University of Milano-Bicocca where he specialises in the use of mass spectrometry imaging (MSI) as an integrative pathology tool to study molecular alterations associated with disease. In particular, he employs spatial proteomics approaches to detect molecular signatures which have diagnostic, prognostic, or predictive relevance. Much of his work has been dedicated to the study of proteomic alterations occurring within glomerular diseases but has also developed methods to study proteomic and lipidomic heterogeneity in solid tumours.