Mercoledì 4 Dicembre 2024, ore 13
Edificio Asclepio U8 - aula 8
► Diretta webex
Micro and nanoplastics (MNPs) have become ubiquitous environmental pollutants, raising concerns about their potential impact on human health. Polyethylene terephthalate (PET), widely used in food packaging, is particularly significant due to its prevalence and durability.
The breakdown of PET's ester bonds leads to the formation of various oligomeric fragments, including those terminated with hydroxyl, carboxyl, or both groups. These fragments contribute to the diverse array of PET MNPs found in the environment.
Addressing the critical gap in standardized PET MNPs for research, we synthesized different PET MNPs by using acid hydrolysis and glycolysis methods. The physicochemical properties of the MNPs were characterized using dynamic light scattering (DLS), zeta potential measurements, and Fourier-transform infrared spectroscopy (FTIR).
These characterizations have revealed differences in surface chemistry, size distribution, and the oligomeric fragments generated.
Preliminary studies on the biological activity of PET MNPs have focused on macrophage viability and their association with pyroptosis through IL-1β release. The interaction of MNPs with the microbiota is also crucial in understanding their potential effects on gut health. By simulating gastrointestinal conditions and incubating MNPs with microbial communities, the research aims to shed light on these effects. Furthermore, we collaborated with clinical partners to analyze MNPs accumulation across human colon samples aiming to obtain a clear picture of their occurrence across different age groups.
This comprehensive approach aims to enhance understanding of PET MNPs' environmental and health impacts, fostering interdisciplinary collaborations to address this pressing issue.
Mohammed Monsoor Shaik
Dr. Mohammed Monsoor Shaik earned his Ph.D. in Biological Sciences from India, where he developed novel bilayer scaffolds for chronic wound healing. With interdisciplinary experience bridging biology and chemistry, Dr. Shaik synthesized and characterized novel vaccine adjuvants during his postdoctoral research at the University of Milano-Bicocca, Italy and CIC bioGUNE, Spain.
He is currently applying his expertise in material synthesis and
characterization to the study of microplastics, investigating their biological interactions and
potential health impacts. His work exemplifies the integration of biology and chemistry to address pressing environmental and health challenges.