Mercoledì 26 Aprile 2023,
ore 13 Edificio Asclepio U8-Aula 3
Department Research Meeting
Preclinical molecular imaging: applications in glioblastoma
Silvia Valtorta Institute of Bioimaging and Molecular Physiology of National Research Council (IBFM-CNR)
Molecular imaging is a rapidly emerging field with a multitude of characteristics that allow to visualize, characterize and quantify, non-invasively, biological processes and phenomena that occur at molecular and cellular levels, inside living organisms. With regard to the requirement to replace, refine and reduce (the 3Rs) the use of animals in research, molecular imaging can be used to follow tumor development or therapeutic effect over a period of time in the same animal, thereby reducing the number of animals being used while simultaneously improving the data set as each animal serves as its own control. A further benefit of sequentially studying tumor pathogenesis in one animal is that information regarding the possible behavior of a tumor in humans, especially regarding metastasis and therapy response, is more achievable. The increase of available radiopharmaceuticals, probes, and technologies allows to monitor a wide spectrum of biological processes. Today, I will share the applications of molecular imaging on models of glioblastoma starting from the characterization of the models until the monitoring of therapy response and the identification of potential biomarkers of therapy in synergy with other –omics sciences.