Department research meeting - Giorgio Cattoretti "DNA damage response in vivo in untreated colon cancer"

DNA damage response in vivo in untreated colon cancer – Giorgio Cattoretti

Mercoledì 25 maggio ore 13:00

Edificio Asclepio ex-U8 Aula 3

Webex link https://unimib.webex.com/unimib/j.php?MTID=me1d8033de9c7d24dff30ee52a1206c63 

Genetic inactivation of tumor suppressor genes (TSG) is a required step during the development of cancer. TSG protect the cell from DNA damage. A third of untreated colon cancer cases at diagnosis show foci of DNA Damage Repair (DDR; gH2AX+, pCHK2+, pNBS1+) in which apoptosis is absent, proliferation is nil, there is no senescence (p16neg, p21neg) and the presence of TP53 is irrelevant. The phenotype do not align with common knowledge about DDR. The findings are discussed.

Giorgio Cattoretti, MD and Surgical Pathologist (both Italian and USA certification), experience in hematopathology and immune techniques, spent the last five years in unraveling the secrets of the routinely processed tissue section (FFPE); starting from this work, he and his collaborators entered the booming world of single cell biology, in situ, opening to many of his colleagues Pathology 2.0 (i.e. a couple of Surgical Pathologists).