Giovedì 26 Giugno 2025, ore 13
Edificio Asclepio U8 - aula 3
Invited Research Meeting
(Host: Prof.ssa Moresco)
♦ Segui la diretta
Illuminating the brain: cutting-edge imaging solutions for neuroscience discovery
Dr. Stefano Abbiati - Dr.ssa Beatrice D'Ulivo - Dr. Giuliano Cazzola | Miltenyi Biotec Italia
Modalità di partecipazione: seminario in presenza con possibilità di collegamento remoto.
Light-sheet microscopy is a leading technology for 3D imaging of biological tissues.
TheUltraMicroscope BlazeTM (Miltenyi Biotec) enables high-resolution imaging of whole cleared samples,preserving spatial and anatomical context. Integrated with 3D immunofluorescence (3D-IF) and tissue clearing protocols, it allows detailed analysis of cellular architecture in neuroscience, oncology, and immunology.
A recent study by Bastiancich et al. (J Exp Clin Cancer Res, 2024) used this technology to investigate the post-surgical glioblastoma (GBM) microenvironment in mouse models. The study revealed a dynamic immune response and transient blood-brain barrier permeability after tumor resection. 3D imaging enabled visualization of microglial and myeloid cell distribution and morphology during early recurrence, identifying potential therapeutic windows for local and systemic interventions.
A further step forward is the integration of 3D imaging with 2D hyper-multiplex analysis using MACSimaTM Imaging Cyclic Staining (MICS). The 3D–2D workflow reveals regions of interest within the 3D volume and enables in-depth 2D molecular profiling, by detecting hundreds of protein markers simultaneously.
This approach offers unprecedented spatial and functional insights into tissue organization.
The seminar will highlight this integrated platform and its role in translational research workflows, with a focus on oncology and neurology for identifying novel therapeutic strategies.
Stefano Abbiati, PhD is a Field Application Specialist at Miltenyi Biotec Italy, where he supports researchers in implementing advanced technologies for cell analysis and imaging.
With a strong background in biotechnology and significant industry experience, he is committed to facilitating the adoption of innovative solutions in neuroscience and oncology.
His role involves technical training, experimental protocol optimization, and post-sales support, contributing to the success of customers’ research projects.
Beatrice D’Ulivo, PhD is an Associate Account Manager Research, Miltenyi Biotec Italy based in Villasanta, Lombardy. Graduated from the University of Verona, she supports researchers in the life sciences by providing tailored solutions for immunological, oncological, and neurological research.
Her work includes both technical and commercial consulting, helping the scientific community access cutting-edge technologies.
Giuliano Cazzola, MSc is a Product Manager at Miltenyi Biotec Italy, with over three years of experience at the company. He holds a Master’s degree from Bologna Business School and has developed expertise in marketing and market analysis within the biotechnology sector. In his current role, he is responsible for product portfolio management, market needs assessment, and strategic planning for the introduction of new technologies, with a strong focus on innovative solutions for biomedical research.